This medication was designed to be unrefrigerated for shipment and has been tested to be stable in extreme temperatures, however it should be taken inside and put in the refrigerator the day of delivery to ensure longevity and freshness of the product. If you will not be home at any point the day of delivery, please reach out to customer service to see if your delivery schedule can be adjusted or have your shipping address updated. You can reach us at support@enhance.md or give us a call at 888-299-5088.